Promoted Papilloma Formation in a Two-Stage Carcinogenesis Model in <i>Rassf6</i> Knockout Mice

Tumor Formation in Two-Stage Skin Carcinogenesis Impairment of Epidermal Hyperplasia and Enhancement of in Mice

We generated a mouse strain lacking protein kinase CA (PKCA) and evaluated the significance of the enzyme in epithelial hyperplasia and tumor formation. PKCA-deficient mice exhibited increased susceptibility to tumor formation in two-stage skin carcinogenesis by single application of 7,12dimethylbenz(a)anthracene (DMBA) for tumor initiation and repeated applications of 12-O-tetradecanoylphorbol...

Parameter Estimation in a Two-stage Model of Carcinogenesis

Two-Stage Nerve Graft in Severe Scar: A Time-Course Study in a Rat Model

excessive scarring; paralleling the process in tendon reconstruction of the hand. Inspired by the advantages of the two-stage technique in tendon grafting and with encouraging preliminary results, we aimed to investigate the two-stage nerve grafting technique as an alternative method of secondary nerve repair. Methods:  Thirty female rats (~200 g) were randomly distributed into two groups (n=15...

A two stage model for Cell Formation Problem (CFP) considering the inter-cellular movements by AGVs

This paper addresses to the Cell Formation Problem (CFP) in which Automated Guided Vehicles (AGVs) have been employed to transfer the jobs which may need to visit one or more cells. Because of added constraints to problem such as AGVs’ conflict and excessive cessation on one place, it is possible that AGVs select the different paths from one cell to another over the time. This means that the ti...

Statistical properties of a two-stage model of carcinogenesis.

Some of the statistical properties of a simple two-stage model of carcinogenesis are explored. The implications of additive treatment effects versus independent treatment effects on the shape of the dose-response curve are considered. Response that is low-dose linear results in the cases where the mutation rates are affected by dose or in the cases where treatment changes the birth rate/death r...